Use of soluble epoxide hydrolase inhibitors in the treatment of inflammatory vascular diseases
AssigneeArete Therapeutics, Inc.
InventorsYi-Xin Wang, Le-Ning Zhang, Gabor M. Rubanyi
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compositions and methods for treating inflammatory vascular diseases. Examples of inflammatory vascular disease include, but are not limited to, in-stent stenosis, coronary arterial diseases (CAD), angina, acute myocardial infarction, acute coronary syndrome, chronic heart failure (CHF), peripheral arterial occlusive diseases (PAOD), critical limb ischemia (CLI), cardiac, kidney, liver and intestinal ischemia, renal failure, cardiac hypertrophy, atherosclerosis, abdominal aortic aneurysm, vasculitis, carotid artery stenosis.
Claims33
A method for treating inflammatory vascular disease in a subject, comprising administering to the subject an effective amount of a soluble epoxide hydrolase (sEH) inhibitor.
A method of treating a disease mediated at least in part by angiotensin II in a subject, comprising administering to the subject an effective amount of a sEH inhibitor.
A method of identifying a disease treatable by a sEH inhibitor in a diseased subject, wherein said method comprises:
- a) assaying a level of angiotensin II in said diseased subject to determine if said level is abnormal;
- and
- b) treating said diseased subject identified in a) above with abnormal level of angiotensin II with an sEH inhibitor.
A stent comprising a surface, wherein the surface comprises a biodegradable composition coating comprising an sHE inhibitor.
Dependencies are inferred from the claim text.