Gelatin-transglutaminase hemostatic dressings and sealants

A composition comprising a combination of gelatin and non-toxic cross-linking agent, wherein a ratio of an amount of said gelatin and an amount of said non-toxic cross-linking agent is sufficient to reduce bleeding in a wound of a mammal, wherein said gelatin does not undergo thermoreversible gelation at room temperature and wherein said gelatin is produced from animal origin, recombinant origin or a combination thereof.

30-32. (canceled)

(canceled)

(canceled)

(canceled)

45-57. (canceled)

A composition for inducing hemostasis and/or sealing a wound, comprising a mixture of gelatin and transglutaminase, wherein said mixture is modified such that said gelatin forms a solution with transglutaminase at a temperature lower than the natural sol-gel transition temperature of standard animal gelatin.

64-68. (canceled)

The composition of claim 68, further comprising an adjusting agent selected from the group consisting of a pH adjusting agent and an ion concentration adjusting agent.

(canceled)

79-82. (canceled)

85-89. (canceled)

A hemostatic or sealing dressing which comprises:

• (i) a first gelatin layer;
• (ii) a transglutaminase layer adjacent to said first gelatin layer;
• and (iii) a second gelatin layer adjacent to said transglutaminase layer, wherein the transglutaminase layer is coextensive or noncoextensive with the first gelatin layer and/or the second gelatin layer.

92-94. (canceled)

96-97. (canceled)

100-102. (canceled)