Systems, devices and methods for noninvasive or minimally-invasive estimation of intracranial pressure and cerebrovascular autoregulation

A device for estimating at least one of a cerebrovascular compliance, a cerebrovascular resistance, an assessment of cerebrovascular autoregulation, and an intracranial pressure, based at least in part on estimating parameters and variables of a computational model, the device including:

• a processor, the processor configured to:
• receive arterial blood pressure measurements;
• receive at least one of cerebral blood flow measurements and cerebral blood flow velocity measurements;
• compute and display an estimate of at least one of the cerebrovascular compliance, the cerebrovascular resistance, the assessment of cerebrovascular autoregulation and the intracranial pressure based at least in part on estimating the parameters and the variables of the computational model and the received measurements, the computational model representing the physiological relationships among cerebrovascular flows and pressures, the computational model including at least one resistive element and at least one compliance element and a representation of the intracranial pressure;
• a memory in communication with the processor for storing at least one of the received measurements and the computed estimate;
• and
• a display in communication with the processor for displaying an estimate of at least one of cerebrovascular compliance, cerebrovascular resistance, and intracranial pressure.