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US 2010/0063292 A1Published application
Process for the preparation of trifluoroethoxytoluenes.
AssigneeGrindeks A Joint Stock Company
InventorsDaina Zicane, Janis Jaunbergs
Life of this patent
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Abstract
The present invention relates to an process for the preparation 2,5-bis(2,2,2-trifluoroethoxy)toluene [II]. The compound 2,5-bis(2,2,2-trifluoroethoxy)toluene is useful as intermediate for pharmaceutical industry, especially useful as an intermediate for the preparation of Flecainide and pharmaceutically acceptable salts.
Claims13
1-11. (canceled)
A substituted 1,4-bis(2,2,2-trifluoroethoxy)benzene of the formula [I]
- where R is methyl.
A process for the preparation of 2,5-bis(2,2,2-trifluoroethoxy)toluene of formula [II]
- which process comprises reacting a 2,5-dihalotoluene of the formula [IV]
- wherein X1 and X2 represent halogen, and the X1 and X2 substituents may be the same or different, and R is methyl, with 2,2,2-trifluoroethanol in the presence of an alkali metal and a copper containing material.
Dependencies are inferred from the claim text.