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AssigneeDr. Reddy's Laboratories, Inc.
InventorsBuchi Reddy Reguri, Satyanarayana Bollikonda, Veera Venkata Naga Chandra Sekhar Bulusu, Ravi Kumar Kasturi, Sanjeev Kumar Aavula
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A process for preparation of montelukast or a salt thereof is provided, the process including reacting a late intermediate compound which is 2-[1-[1-R-3-[2-(7 chloro quinolin-2-yl)vinyl [phenyl]-3-[2-methoxy carbonyl phenyl]propyl sulfonyl methyl]cyclo propyl]acetic acid or a salt thereof with methyl magnesium chloride or methyl magnesium bromide in an organic solvent. In one embodiment, the process includes reacting an earlier intermediate compound which is methyl 2-(3-R-(3-(2-(7-chloro 2-quinolinyl)-ethenyl)-3 hydroxy propyl)benzoate with methane sulfonyl chloride or toluene sulfonyl chloride to obtain a mesylated or tosylated derivative of the earlier intermediate compound; followed by a reaction of the mesylated or tosylated derivative with 1-mercapto methyl cyclopropane acetic acid in a polar solvent in a presence of a base to obtain the late intermediate compound.
1-10. (canceled)
The process of claim 28, wherein said montelukast free acid is precipitated from a solvent selected from the group consisting of toluene, methanol, ethanol, isopropanol, ethyl acetate, and mixtures thereof.
12-27. (canceled)
A process for preparing a solid form of montelukast free acid, comprising providing a solution of montelukast free acid in a solvent and forming a solid precipitate that contains montelukast free acid.
A process for preparing a solid form of montelukast free acid, comprising dissolving montelukast free acid in toluene and forming a solid precipitate that contains montelukast free acid.
A process for preparing a solid form of montelukast free acid, comprising providing a solution of montelukast free acid in a solvent and isolating montelukast from a solvent selected from the group consisting of toluene, ethyl acetate, acetonitrile, heptane, hexane and mixtures thereof.
A process for preparing a solid sodium salt of montelukast, comprising synthesizing montelukast free acid in a solution, precipitating solid montelukast free acid, dissolving montelukast free acid in a solvent, converting montelukast free acid into a sodium salt of montelukast, and isolating a solid sodium salt of montelukast.
A process for preparing a sodium salt of montelukast, comprising providing a solution of montelukast free acid in a halogenated solvent, aromatic solvent, or mixtures thereof, converting the montelukast free acid to a sodium salt of montelukast, and precipitating a sodium salt of montelukast.
Dependencies are inferred from the claim text.