Antifungal triazole derivatives, method for the preparation thereof and pharmaceutical composition containing same

A compound of formula (I), or an isomer or pharmaceutically acceptable salt thereof:

• wherein,
• Ar is phenyl substituted with at least one halogen or C1-C4 haloalkyl;
• R1 is hydrogen, fluorine or C1-C4 alkyl;
• R2, R3 and R4 are each independently hydrogen, halogen, C1-C4 alkyl, C1-C4 haloalkyl, C3-C6 cycloalkyl, C1-C4 alkoxy, nitro, cyano, amino, hydroxy, —NR5R6, —CONR5R6, —CH2—CO—R5, —CH2—OCO—R5, —CO—R5, —COOR5, —C(═NR5)NHR7, —C(═NR7)OR7, —SOZR7, —NR5SO2R7 or aryl C1-C4 alky, the aryl moiety being phenyl or naphtyl unsubstituted or substituted with at least one halogen, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 haloalkoxy, nitro, cyano, hydroxy or hydroxymethyl, wherein R4 may represent two or more substituents independently selected from the above-mentioned substituents;
• X is C1-C4 alkyl, C1-C4 alkenyl or C1-C4 alkynyl unsubstituted or substituted with at least one halogen;
• O;
• NR2;
• CONR2;
• R2—O;
• R2—NR3;
• R2—OR3;
• R2—CO—R3;
• or Q-P unsaturated or substituted with O or C1-C4alky;
• Q being a linker, CO or C1-C4 alkyl, and P being a 5- to 7-membered heterocyclic ring containing at least one nitrogen or oxygen atom;
• and
• A, B, D, E and G are each independently nitrogen or carbon fused together to form a phenyl, pyridine, pyrimidine or triazine group, which is optionally fused with X to form a ring,
• in which
• R5 is hydrogen, C1-C4 alkyl, C3-C6 cycloalkyl, —COCF3, or the aryl C1-C4 alkyl defined for R2;
• R6 is hydrogen, —CONH2, —COCH3, —CN, or —(C1-C4 alkyl)-NH2;
• R7 is C1-C4 alkyl, C3-C6 cylcoalkyl, or the aryl C1-C4 alkyl defined for R2;
• and
• Z is 0, 1, or 2.