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US 2010/0063257 A1Published application
Purification of FC-TACI Fusion Proteins Using the Oilbody Technology
AssigneeMerck Serono SA
InventorsHenri Kornmann, Gianni Baer
Life of this patent
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Abstract
The invention relates to a process for the purification of Fe-fusion proteins such as TACI-Fc using genetically engineered oilbodies expressing protein A.
Claims21
1-17. (canceled)
A method for purifying a TACT-Fc protein comprising:
- a) mixing a solution comprising protein A oilbodies with a sample comprising a TACI-Fc protein to obtain a final ratio of TACT-Fc protein to dry-weight oilbodies 1 to 5.5 (w/w);
- and
- b) separating said protein A oilbodies from said TACI-Fc protein by adding an aqueous solution having a pH of 2.7 to 5.
Dependencies are inferred from the claim text.