Polymorphs of acyl sulfonamides
AssigneeRoche Palo Alto LLC
InventorsJames Prentice Davidson, Fei Pang, Margaret Wong, Michael Martin
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Abstract
The application discloses novel polymorphic crystalline forms of 2-[4-Bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-propionylsulfamoyl-phenyl)-acetamide, sodium salt (Ib) with improved stability and physical properties which facilitate manufacturing, handling and formulating for treatment or prophylaxis of HIV mediated diseases, AIDS or ARC, in monotherapy or in combination therapy.
Claims21
A crystalline form of a compound according to formula Ib.
A method of treating a disease associated with HIV comprising administering to a patient in need thereof, a therapeutically effective amount of the amorphous state of Ib.
A pharmaceutical composition comprising of the amorphous state of Ib in admixture with at least one pharmaceutically acceptable carrier, diluent or excipient.
Dependencies are inferred from the claim text.