Anti-cholesterolemic compounds and methods of use
AssigneesThe Johns Hopkins University, Merlion Pharmaceutical Pte Ltd.
InventorsSubroto Chatterjee, Mark S. Butler, Brinda Somanadhan
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Abstract
The present invention provides novel compounds with hypocholesteremic activity from crude Embilica officinialis (EO) extracts and methods of use. The invention also provides nutraceuticals.
Claims21
A method for preventing or treating an elevated blood lipid level-related disease or disorder in a subject comprising administering to the subject an effective amount of one or more gallic acid derivatives, thereby preventing or treating an elevated blood lipid level-related disease or disorder in the subject.
A method for preventing or treating inflammation in a subject comprising administering to the subject an effective amount of one or more gallic acid derivatives, thereby preventing or treating inflammation in the subject.
A method for preventing or treating a stress response in a subject comprising administering to the subject an effective amount of one or more gallic acid derivatives, thereby preventing or treating a stress response in the subject.
5-7. (canceled)
A method of reducing cholesterol biosynthesis in a subject comprising administering an effective amount of one or more gallic acid derivatives, thereby reducing cholesterol biosynthesis in a subject.
A method of increasing the cellular efflux of cholesterol in a subject comprising administering an effective amount of one or more gallic acid derivatives, thereby increasing the cellular efflux of cholesterol in a subject.
A method of inhibiting the cellular uptake of cholesterol in a subject comprising administering an effective amount of one or more gallic acid derivatives, thereby inhibiting the cellular uptake of cholesterol in a subject.
A method of inhibiting the oxidation of LDL comprising administering an effective amount of one or more gallic acid derivatives, thereby preventing the oxidation of LDL.
13-21. (canceled)
A pharmaceutical composition for the treatment or prevention of an elevated blood lipid level-related disease or disorder comprising one or more gallic acid derivatives and a pharmaceutically acceptable excipient.
23-35. (canceled)
A kit for the use in preventing or treating an elevated blood lipid level-related disease in a mammal comprising one or more gallic acid derivatives.
37-40. (canceled)
A kit for the use in preventing or treating an elevated blood lipid level related disease or disorder in a subject comprising one or more gallic acid derivatives, and instructions for use.
A kit for the use in preventing or treating inflammation in a subject comprising one or more gallic acid derivatives, and instructions for use.
A kit for the use in preventing or treating a stress response in a subject comprising one or more gallic acid derivatives, and instructions for use.
A kit for use in reducing cholesterol biosynthesis, increasing the cellular efflux of cholesterol, or inhibiting the cellular uptake of cholesterol comprising one or more gallic acid derivatives, and instructions for use.
46-47. (canceled)
Dependencies are inferred from the claim text.