Method and Topical Formulation for Treating Localized Edema
AssigneeLIVIONEX, Inc.
InventorsRajiv Bhushan, Jerry B. Gin, Amit Goswamy
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Abstract
Methods and formulations are provided for the treatment of localized edema, particularly localized edema resulting from chronic venous insufficiency. A metal ion sequestrant is topically administered to a subject afflicted with localized edema in combination with a permeation enhancer selected from methylsulfonylmethane and a combination of methylsulfonylmethane and dimethylsulfoxide. Topically administrable formulations for use in the aforementioned method are also provided.
Claims26
A method for treating localized edema in a patient, comprising topically applying to the patient at the site of the localized edema a therapeutically effective amount of a metal ion sequestrant and an effective permeation-enhancing amount of a permeation enhancer selected from methylsulfonylmethane and a combination of methylsulfonylmethane and dimethylsulfoxide.
A topically administrable formulation for the treatment of localized edema, comprising a therapeutically effective amount of a metal ion sequestrant, an effective permeation enhancing amount of a permeation enhancer selected from methylsulfonylmethane and a combination of methylsulfonylmethane and dimethylsulfoxide, and a pharmaceutically acceptable topical carrier, wherein the formulation comprises a lotion, cream, or gel.
Dependencies are inferred from the claim text.