Novel substituted sulfamide derivatives
AssigneeJanssen Pharmaceutica NV
InventorsDavid F. McComsey, Michael H. Parker
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Abstract
The present invention is directed to novel substituted sulfamide derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives form in the treatment of anxiety and related disorders; bipolar depression and mania; depression; epilepsy and related disorders; epileptogenesis; glucose related disorders; lipid related disorders; migraine; obesity; pain; substance abuse and as neuroprotective agents. The present invention is further directed to a process for the preparation of the novel substituted sulfamide derivatives.
Claims22
A compound of formula (I)
- wherein
- R1 is selected from the group consisting of C1-4alkyl and —O-phenyl;
- wherein the phenyl is optionally substituted with one to three substituents, independently selected from the group consisting of halogen, C1-4alkyl, fluorinated C1-4alkyl, C1-4alkoxy, fluorinated C1-4alkoxy, cyano, nitro, —NRARB and —C(O)—NRCRD;
- wherein RA and RB are each independently selected from the group consisting of C1-4alkyl;
- and wherein RC and RD are each independently selected from the group consisting of hydrogen and C1-4alkyl;
- or a pharmaceutically acceptable salt thereof;
- provided that when R1 is methyl, then the compound of formula (I) is present as an isolated or a substantially pure form.
A compound of formula (A)
- or a pharmaceutically acceptable salt thereof;
- wherein the compound of formula (A) is present as an isolated or a substantially pure form.
A process for the preparation of a compound of formula (I)
- wherein
- R1 is selected from the group consisting of C2-4alkyl and —O-phenyl;
- wherein the phenyl is optionally substituted with one to three substituents, independently selected from the group consisting of halogen, C1-4alkyl, fluorinated C1-4alkyl, C1-4alkoxy, fluorinated C1-4alkoxy, cyano, nitro, —NRARB and —C(O)—NRCRD;
- wherein RA and RB are each independently selected from the group consisting of C1-4alkyl;
- and wherein RC and RD are each independently selected from the group consisting of hydrogen and C1-4alkyl;
- or a pharmaceutically acceptable salt thereof;
- comprising
- reacting a compound of formula (S) with a compound of formula (X), wherein X is a leaving group;
- in an organic solvent;
- to yield the corresponding compound of formula (I).
A process for the preparation of a compound of formula (A)
- or a pharmaceutically acceptable salt thereof;
- comprising
- reacting a compound of formula (S) with a compound of formula (X-A), wherein X is a leaving group;
- in an organic solvent;
- to yield the corresponding compound of formula (A).
Dependencies are inferred from the claim text.