Cytotoxin Compound And Method of Isolation
AssigneesUniversity of South Florida, The UAB Research Foundation
InventorsBill J. Baker, Thushara Diyabalanage, James B. McClintock, Charles D. Amsler
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Abstract
The present invention concerns compounds derived from tunicates of the species Synoicum adareanum, as well as to pharmaceutical compositions comprising these compounds and methods of use. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
Claims33
A method of treating a subject with cancer or a cell proliferation disorder, comprising administering to the subject a therapeutically effective amount of at least one isolated compound obtained from extracts of a Synoicum species, or a composition comprising said compound.
A composition comprising an isolated compound obtained from extracts of a Synoicum species.
A method for inhibiting the proliferation of a cell, comprising contacting said cell with an effective amount of an isolated compound obtained from extracts of a Synoicum species, or a composition comprising said compound.
Dependencies are inferred from the claim text.