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US 2010/0063135 A1Published application
Polyethylene glycol lipid conjugates and uses thereof
AssigneeAbbott Laboratories
InventorsPrasad A. Dande, Todd M. Hansen, Robert D. Hubbard, William E. Kohlbrenner, Leiming Li, Aparna V. Sarthy, Yu Shen, Lu Tian, Carol K. Wada, Xiaobin Zhao
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Abstract
Polyethylene glycol (PEG)-lipid conjugates, polyethylene glycol (PEG)-lipid conjugate based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
Claims78
A polyethylene glycol (PEG)-lipid conjugate having Formula I
- wherein
- R1 and R2 are independently R3, or C(O)R3;
- or
- R1 and R2 together are C(R3)2;
- R3 is C8-C24 alkyl;
- L is C(OCH3)2, NHC(O), C(O)NH, OC(O)NH, NHC(O)O, NHC(O)NH, N(N)C(O), C(O)N(N), SS, NHC(O)L2C(O)O, NHC(O)L2C(O)NH, OC(O)L2C(O)O, OC(O)L2C(O)NH, C(O)O, OC(O), S, O, CH2CH(═N)NHR4C(O), or C(═NNHCH3)R4;
- R4 is aryl or heteroaryl;
- L2 is C1-C6 alkyl;
- X is a bond or C1-C6 alkyl;
- and
- n is 10-200.
8 more elements
Dependencies are inferred from the claim text.