Small interfering rna and pharmaceutical composition for treatment of hepatitis b comprising the same
AssigneeMogam Biotechnology Research Institute
InventorsMeehyein KIM, Duckhyang Shin, Soo In Kim, Mahnhoon Park
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Abstract
The present invention relates to RNA interference mediated inhibition of Hepatitis B virus (HBV) by short interfering RNA (siRNA) molecules. Specially, siRNAs of the present invention which are double-stranded RNAs concern directing the sequence-specific degradation of viral RNA in mammalian cells. Disclosed is a DNA vector encoding the RNA molecules and synthesized siRNA molecules as well as method of therapeutic treatment for inhibition of HBV gene expression and viral replication by the administration of RNA molecules of the present invention.
Claims18
An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:
- 3, or a complement thereof, or a portion thereof.
A DNA vector comprising a DNA sequence corresponding to a nucleotide sequence selected from the group of SEQ ID NO:3, or a complement sequence thereof, or a portion thereof.
Dependencies are inferred from the claim text.