New pyrazole derivatives and diabetic medicine containing them

A pyrazole compound of formula (1A) or a pharmaceutically acceptable salt thereof:

• wherein
• X represents a β-D-glucopyranosyl group, of which one or more hydroxyl groups may be acylated or β-D-glucuronyl group, of which one or more hydroxyl groups may be acylated and a carboxyl group may be esterified;
• Y represents a lower alkyl group or a perfluoro lower alkyl group;
• Z represents a hydrogen atom, a lower alkyl group, a perfluoro lower alkyl group, an aralkyl group or a phenyl group;
• R1, R2, R4, and R5 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a perfluoro lower alkyl group, a lower alkoxy group, a perfluoro lower alkoxy group, a lower alkylthio group, a perfluoro lower alkylthio group, a lower alkyl amino group, a halogeno group, a lower alkanoyl group, a lower alkenyl group or a lower alkynyl group;
• and
• n represents an integer from 1 to 3,
• wherein at least one of R1, R2, R4, and R5 represents a lower alkyl group having 1 to 6 carbon atoms, lower alkylthio group having 1 to 6 carbon atoms, halogeno atom, lower alkoxy group, lower alkenyl group or lower alkynyl group;
• and
• R3 represents a lower alkyl group having 1 to 6 carbon atoms, a lower alkylthio group having 1 to 6 carbon atoms, a halogeno atom, a lower alkoxy group, a lower alkenyl group, or a lower alkynyl group.