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US 2010/0063114 A1Published application
Inhibitors of protein prenyltransferases
AssigneeThe Regents of the University of California
InventorsFuyuhiko Tamanoi, Ohyun Kwon, Masaru Watanabe, Hannah Fiji
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Abstract
The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of GGTase I. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.
Claims28
A compound having the formula
- wherein J is hydrogen or is 1-2 substituents selected from the group consisting C1-C3 alkyl and halogen,
- wherein G is
- wherein E is selected from the group consisting of hydrogen, C1-C3 alkyl, and halogen,
- wherein W is selected from the group consisting of cyclic, linear, or branched alkyl of from 2 to 8 carbons, unsubstituted phenyl, and phenyl substituted with C1-C3 alkyl, hydrogen, or halogen,
- wherein X—Y is selected from the group consisting of
- wherein A is selected from the group consisting of
- and —CO2M;
- wherein M is selected from the group consisting of hydrogen and alkyl of from 1 to 2 carbons,
- “wherein n is between 0 and 3 carbons;
- wherein R is any alpha-substituent of an amino acid;
- wherein Z is S—U;
- and
- wherein U is selected from the group consisting of alkyl of from 2 to 10 carbons;
- and salts of the compound.
11 more elements
A compound or salt thereof having the formula:
A compound or salt thereof having the formula:
A compound having the formula:
Dependencies are inferred from the claim text.