Thiadiazolidinone derivatives
AssigneeUniversity of Rochester
InventorsCraig Jordan, Monica Guzman
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Abstract
The present invention relates to compounds of the formulae herein, their acceptable salts, solvates, hydrates and polymorphs thereof. The compounds of this invention are useful in treatment of disease, particularly leukemia. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating disease, disorders, or symptoms thereof in a subject.
Claims22
A method for treating leukemia in a subject comprising administration to the subject of a compound of Formula (I):
- or a salt thereof;
- or a prodrug or a salt of a prodrug thereof;
- or a hydrate, solvate or polymorph thereof;
- wherein:
- A is —C(R1)2—, —O— or —NR1—;
- E is —NR1— or —CR1R2— and the substituent R2 is absent if - - - is a second bond between E and G;
- G is —S—, —NR1— or —CR1R2— and the substituent R2 is absent if - - - is a second bond between E and G;
- - - - may be a second bond between E and G where the nature of E and G permits and E with G optionally then forms a fused aryl group;
- R1 and R2 are each independently selected from hydrogen, alkyl, cycloalkyl, haloalkyl, aryl, -(Z)n-aryl, heteroaryl, —OR3, —C(O)R3, —C(O)OR3, -(Z)n-C(O)OR3 and —S(O)t— or as indicated R2 can be such that E with G then form a fused aryl group;
- Z is independently selected from —C(R3)(R4)—, —C(O)—, —O—, —C(═NR3)—, —S(O)t— and N(R3)—;
- n is zero, one or two;
- t is zero, one or two;
- R3 and R4 are each independently selected from hydrogen, alkyl, aryl and heterocyclic;
- and X and Y are each independently selected from ═O, ═S, ═N(R3) and ═C(R1)(R2).
A method for treating leukemia in a subject comprising administration to the subject of a compound of Formula (II):
- or a salt thereof;
- or a prodrug, or a salt of a prodrug thereof;
- or a hydrate, solvate, or polymorph thereof;
- wherein:
- each R1 and R2 are each independently selected from hydrogen, alkyl, cycloalkyl, haloalkyl, aryl, -(Z)n-aryl, heteroaryl, —OR3, —C(O)R3, —C(O)OR3, -(Z)n-C(O)OR3 and —S(O)t— or as indicated R2 can be such that E with G then form a fused aryl group;
- Z is independently selected from —C(R3)(R4)—, —C(O)—, —C(═NR3)—, —S(O)t— and N(R3)—;
- n is zero, one or two;
- t is zero, one or two;
- R3 and R4 are each independently selected from hydrogen, alkyl, aryl and heterocyclic;
- and X and Y are each independently selected from ═O, ═S, ═N(R3) and ═C(R1)(R2).
Dependencies are inferred from the claim text.