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US 2010/0063107 A1Published application
Hydroxy methyl phenyl pyrazolyl urea compounds usefull in the treatment of cancer
AssigneeBayer HealthCare LLC
InventorsRoger Smith, Dhanapalan Nagarathnam
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Abstract
The compound 4-{4-[({3-tert-Butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide and alternative forms thereof (e.g., salts, solvates, hydrates, prodrugs, polymorphs and metabolites); pharmaceutical compositions which contain them; and methods for treating cancer using them.
Claims19
A compound which is
- 4-{4-[({3-tert-Butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)-amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, a pharmaceutically acceptable salt thereof, a metabolite thereof, a solvate thereof, a hydrate thereof, a prodrug thereof, or a polymorph thereof or a diastereoisomeric form of the salt or prodrug thereof, both as an isolated stereoisomer or within a mixture of stereoisomers.
A pharmaceutical composition comprising:
- a compound which is 4-{4-[({3-tert-Butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, a pharmaceutically acceptable salts thereof, a metabolite thereof, a solvate thereof, a hydrate thereof, a prodrug thereof or a polymorph thereof or a diastereoisomeric form of a salt or prodrug thereof, either as an isolated stereoisomer or within a mixture of stereoisomers, and a physiologically acceptable carrier.
Dependencies are inferred from the claim text.