US 2010/0063104 A1 · NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF

Abstract

It is intended to provide a compound represented by the formula (I): wherein all the symbols are as defined in the description; which has a p38 MAP kinase inhibitory activity, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. The compound of the invention is useful for preventing or treating a disease in which the abnormal production of a cytokine such as an inflammatory cytokine or a chemokine or overreaction to them is considered to be involved in the cause and aggravation of pathological conditions, in other words, an inflammatory disease, a respiratory disease, a cardiovascular disease, a central nervous system disease or the like, which is a cytokine-mediated disease.

Claims24

Dependent claims

A compound represented by formula (I):

wherein ring A represents a 5-membered monocyclic hetero ring which contains 1 to 3 atom(s) selected from the group consisting of an oxygen atom, a nitrogen atom and a sulfur atom, and which may have a further substituent(s);
ring B represents a hetero ring which may be substituted and may contain 1 to 3 atom(s) selected from the group consisting of an oxygen atom, an nitrogen atom and a sulfur atom in addition to the described nitrogen atom;
ring D represents a cyclic group which may be substituted;
ring E represents a cyclic group which may be substituted;
and
R1 represents a neutral group or an acidic group which contains an oxygen atom(s) and/or a sulfur atom(s);
or a salt thereof, N-oxide or solvate thereof, or a prodrug thereof.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

12/089,108Filed 2 Oct 2006

Priority

JP 2005-2895423 Oct 2005

Published

11 Mar 2010

Term ends

Not estimatedThe source records don’t support an estimate.

Classification54 codes

A61K 31/00
Medicinal preparations containing organic active ingredients
A61K 31/4439
Containing further heterocyclic ring systems: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…

Nitrogen-containing heterocyclic compound and pharmaceutical application thereof

Life of this patent

Nitrogen-containing heterocyclic compound and pharmaceutical application thereof

Life of this patent

Abstract

Claims24