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US 2010/0063101 A1Published application
New benzimidazole derivatives
AssigneeHoffmann-La Roche Inc.
InventorsGregory Martin Benson, Konrad Bleicher, Song Feng, Uwe Grether, Bernd Kuhn, Rainer E. Martin, Jean-Marc Plancher, Hans Richter, Sven Taylor
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Abstract
The invention is concerned with novel benzimidazole derivatives of formula (I) wherein A, n and R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.
Claims23
A compound of formula (I):
- or a pharmaceutically acceptable salt or ester thereof, wherein:
- A is oxygen, sulfur, SO2, CH2 or NR8;
- R1 is hydrogen or halogen;
- R2 is hydrogen or halogen;
- R3 is phenyl or pyridinyl, wherein said phenyl or pyridinyl is optionally substituted with one to three substituents independently selected from the group consisting of alkyl, haloalkyl, alkoxy and halogen;
- R4 is alkyl, cycloalkyl, halocycloalkyl or phenyl;
- R5 and R6 are independently hydrogen or alkyl;
- or alternatively R5 and R6 together with the carbon atom to which they are attached form cycloalkyl;
- R7 is cycloalkyl, phenyl, pyridinyl, pyrimidinyl, or thieno[2,3-c]pyridinyl;
- which is optionally substituted with one to three substituents independently selected from the group consisting of:
- (1) alkyl, (2) haloalkyl, (3) alkoxy, (4) carboxy, (5) carboxyalkoxy, (6) carboxycycloalkoxy, (7) halogen, (8) isoxazol-3-one-5-yl, (9) 1H-tetrazol-5-yl, (10) [1,2,4]oxadiazolidin-3,5-dione-2-yl, (11) thiazolidin-2,4-dione-5-yl, and (12) imidazolidin-2,4-dione-5-yl;
- R8 is hydrogen, alkyl or haloalkyl;
- and
- n is 0 or 1.
11 more elements
Dependencies are inferred from the claim text.