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US 2010/0063100 A1Published application
Modulators of aldehyde dehydrogenase activity and methods of use thereof
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsCHE-HONG CHEN, Daria Mochly-Rosen, Wenjin Yang
Life of this patent
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Abstract
The present invention provides compounds that function as modulators of aldehyde dehydrogenase activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition.
Claims24
A compound of Formula I:
- wherein each of R1, R2, and R3 is independently selected from H;
- a halo;
- a substituted or unsubstituted phenyl group;
- an aliphatic group, an alkyl group;
- a substituted alkyl group;
- an alkenyl group;
- an alkynyl group;
- a substituted or unsubstituted cyclic group;
- a substituted or unsubstituted heterocyclic group;
- a substituted or unsubstituted aryl group;
- and a substituted or unsubstituted heteroaryl group;
- wherein A is C or S and where a=1 when A=C;
- and where a=2 when A=S;
- and
- wherein Ar1 and Ar2 are independently selected from a substituted aryl group, an unsubstituted aryl group, a substituted heteroaryl group, and an unsubstituted heteroaryl group;
- or a pro-drug, a pharmaceutically acceptable salt, an analog, or a derivative thereof.
13 more elements
A compound of Formula II:
- wherein Xn and Xy are each independently H, C, N, O, or a halogen (e.g., F, Br, Cl, or I);
- where n is the integer 0 or 1;
- where y is the integer 0 or 1;
- wherein . . . (dotted line) is an optional bond;
- where z is the integer 0, 1, or 2;
- wherein A is C or S, and where a=1 when A=C;
- and where a=2 when A=S;
- wherein Ar is an unsubstituted or substituted aryl group, a substituted heteroaryl group, or an unsubstituted heteroaryl group;
- and
- wherein R1 to R6 is each independently selected from H;
- a halo;
- a substituted or unsubstituted phenyl group;
- an aliphatic group, an alkyl group;
- a substituted alkyl group;
- an alkenyl group;
- an alkynyl group;
- a substituted or unsubstituted cyclic group;
- a substituted or unsubstituted heterocyclic group;
- a substituted or unsubstituted aryl group;
- and a substituted or unsubstituted heteroaryl group;
- or a pro-drug, a pharmaceutically acceptable salt, an analog, or a derivative thereof.
18 more elements
A compound of Formula a:
- wherein R1 to R4 is each independently selected from H;
- a halo;
- an aliphatic group;
- an alkyl group;
- a substituted alkyl group;
- an alkenyl group;
- an alkynyl group;
- a substituted or unsubstituted cyclic group;
- an ether;
- a substituted or unsubstituted amine;
- an ester;
- and an amide group;
- or a pro-drug, a pharmaceutically acceptable salt, an analog, or a derivative thereof.
10 more elements
A compound of Formula b:
- wherein R1 to R4 is each independently selected from H;
- a halo;
- an aliphatic group;
- an alkyl group;
- a substituted alkyl group;
- an alkenyl group;
- an alkynyl group;
- a substituted or unsubstituted cyclic group;
- an ether;
- a substituted or unsubstituted amine;
- an ester;
- and an amide group;
- or a pro-drug, a pharmaceutically acceptable salt, an analog, or a derivative thereof.
10 more elements
A compound of Formula c:
- wherein R1 to R4 is each independently selected from such group, but not limit to, H;
- a halo (e.g., bromo, fluoro, chloro, iodo);
- an aliphatic group;
- an alkyl group;
- a substituted alkyl group;
- an alkenyl group;
- an alkynyl group;
- a substituted or unsubstituted cyclic group;
- an ether;
- a substituted or unsubstituted amine;
- an ester;
- and an amide group;
- or a pro-drug, a pharmaceutically acceptable salt, an analog, or a derivative thereof.
10 more elements
Dependencies are inferred from the claim text.