Method of treating learning impairment in down's syndrome subjects
AssigneeUniversity Court of the University of Dundee
InventorPhilip Cohen
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Abstract
The present invention provides compounds for use in the preparation of pharmaceutical formulations and medicaments, which alleviate learning and/or mental impairment in people suffering from Down's syndrome.
Claims12
A method of alleviating or minimising a symptom or condition observed in a Down's syndrome subject comprising the step of administering to a Down's syndrome subject a therapeutically effective amount of a compound or salt or hydroxide thereof of the following formula (I)
- wherein R1 is selected from hydrogen;
- substituted or unsubstituted C1-C6 alkyl, alkenyl, or alkyloxy, alkylthio, alkyloxycarbonyl;
- hydroxyl;
- nitro;
- amino;
- halo or oxo;
- R2 and R3 are independently selected from hydrogen;
- substituted or unsubstituted C1-C6 alkyl, alkenyl, or alkyloxy, alkylthio, alkyloxycarbonyl;
- hydroxyl;
- nitro;
- amino or halo;
- and
- R4 is selected from hydrogen;
- substituted or unsubstituted C1-C6 alkyl, alkenyl, or alkyloxycarbonyl;
- the dashed line represents a single or double bond.
A pharmaceutical formulation, comprising a compound or physiologically acceptable salt, hydroxide or other physiologically functional derivative thereof, of the following formula (I)
- wherein R1 is selected from hydrogen;
- substituted or unsubstituted C1-C6 alkyl, alkenyl, or alkyloxy, alkylthio, alkyloxycarbonyl;
- hydroxyl;
- nitro;
- amino;
- halo or oxo;
- R2 and R3 are independently selected from hydrogen;
- substituted or unsubstituted C1-C6 alkyl, alkenyl, or alkyloxy, alkylthio, alkyloxycarbonyl;
- hydroxyl;
- nitro;
- amino or halo;
- and
- R4 is selected from hydrogen;
- substituted or unsubstituted C1-C6 alkyl, alkenyl, or alkyloxycarbonyl;
- the dashed line represents a single or double bond, together with one or more pharmaceutically acceptable carriers therefore and optionally other therapeutic and/or prophylactic ingredients.
Dependencies are inferred from the claim text.