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US 2010/0063073 A1Published application
Methods and Compositions Utilizing Quinazolinones
AssigneeCytokinetics, Inc.
InventorsJeffrey T. Finer, Gustave Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
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Abstract
Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
Claims3
-59. (canceled)
A method of treating breast cancer wherein said breast cancer is responsive to KSP inhibition comprising administering to a patient in need thereof a therapeutically effective dose of N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamide or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.