Substituted aniline derivatives

A compound having the general formula I:

• wherein:
• Z is O or S;
• q is 1;
• R1 and R2 are each independently selected from the group consisting of halogen, cyano, amino, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, C3-8-heterocycloalk(en)yl, Aryl, Heteroaryl, halo-C1-6-alk(en/yn)yl, halo-C3-8-cycloalk(en)yl, halo-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C3-8-cycloalk(en)yloxy, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yloxy, and C3-8-heterocycloalk(en)yloxy;
• R3 is selected from the group consisting of C1-8-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, Aryl-C1-6-alk(en/yn)yl, Aryl-C3-8-cycloalk(en)yl, Aryl-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, C3-8-heterocycloalk(en)yl-C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yl-C3-8-heterocycloalk(en)yl-C1-6-alk(en/yn)yl, Heteroaryl-C1-6-alk(en/yn)yl, Heteroaryl-C3-8-cycloalk(en)yl, Heteroaryl-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, amino-C1-6-alk(en/yn)yl, amino-C3-8-cycloalk(en)yl, amino-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy-C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yloxy-C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yloxy-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, halo-C3-8-cycloalk(en)yl and halo-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl;
• and
• R4 is selected from the group consisting of halogen, cyano, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, C3-8-heterocycloalk(en)yl, Aryl, Heteroaryl, Aryl-C1-6-alk(en/yn)yl, Aryl-C3-8-cycloalk(en)yl, Aryl-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, Aryl-C3-8-heterocycloalk(en)yl, halo-C1-6-alk(en/yn)yl, halo-C3-8-cycloalk(en)yl, halo-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl-C3-8-heterocycloalk(en)yl-C1-6-alk(en/yn)yl, NR5R6 and R7NH—C1-6-alk(en/yn)yl;
• wherein;
• R5 and R6 are each independently selected from the group consisting of hydrogen, Aryl-C1-6-alk(en/yn)yl, Aryl-C3-8-cycloalk(en)yl, Aryl-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, Heteroaryl-C1-6-alk(en/yn)yl, Heteroaryl-C3-8-cycloalk(en)yl and Heteroaryl-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, with the proviso that R5 and R6 can not both be hydrogen;
• and
• R7 is selected from the group consisting of C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, Aryl, halo-C1-6-alk(en/yn)yl, halo-C3-8-cycloalk(en)yl, halo-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, Aryl-C1-6-alk(en/yn)yl, Aryl-C3-8-cycloalk(en)yl and Heteroaryl;
• or
• Z is O or S;
• q is 0;
• R1 and R2 are each independently selected from the group consisting of C3-8-heterocycloalk(en)yl, Heteroaryl, and C3-8-heterocycloalk(en)yloxy;
• R3 is selected from the group consisting of C3-8-heterocycloalk(en)yl-C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yl-C3-8-heterocycloalk(en)yl-C1-6-alk(en/yn)yl, Heteroaryl-C1-6-alk(en/yn)yl, Heteroaryl-C3-8-cycloalk(en)yl, and Heteroaryl-C3-8-cycloalk(en)yl-C1-16-alk(en/yn)yl;
• and
• R4 is selected from the group consisting of C3-8-heterocycloalk(en)yl, Heteroaryl, Aryl-C3-8-heterocycloalk(en)yl, halo-C1-6-alk(en/yn)yl-C3-8-heterocycloalk(en)yl-C1-6-alk(en/yn)yl, NR5R6 and R7NH—C1-6-alk(en/yn)yl;
• wherein:
• R5 and R6 are each independently selected from the group consisting of Heteroaryl-C1-6-alk(en/yn)yl, Heteroaryl-C3-8-cycloalk(en)yl and Heteroaryl-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl and
• R7 is Heteroaryl;
• or
• a pharmaceutically acceptable salt thereof.