Kinase inhibitor compounds

A compound of formula I or II:

• or a salt thereof;
• or a prodrug, or a salt of a prodrug thereof;
• or a hydrate, solvate, or polymorph thereof;
• wherein:
• R1 is arylalkyl or heteroarylalkyl, each optionally substituted with 1-4 independent Z1;
• R2 is aryl, heteroaryl, heterocyclyl or amide, each optionally substituted with 1-4 independent Z2;
• R3 is hydrogen, hydroxyl, alkoxy, or alkylamino;
• R4 is hydrogen or CH3;
• R5 is hydrogen, NH2, or CH3;
• Each Z1 and Z2 is independently halogen, CN, NO2, OR15, SR15, S(O)2OR15, NR15R16, C1-C2 perfluoroalkyl, C1-C2 perfluoroalkoxy, 1,2-methylenedioxy, C(O)OR15, C(O)NR15R16, OC(O)NR15R16, NR15C(O)NR15R16, C(NR16)NR15R16, NR15C(NR16)NR15R16, S(O)2NR15R16, R17, C(O)R17, NR15C(O)R17, S(O)R17, S(O)2R17, R16, oxo, C(O)R16, C(O)(CH2)nOH, (CH2)nOR15, (CH2)nC(O)NR15R16, NR15S(O)2R17, where n is independently 0-6 inclusive;
• Each R15 is independently hydrogen, C1-C4 alkyl or C3-C6 cycloalkyl;
• Each R16 is independently hydrogen, alkenyl, alkynyl, C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or C1-C4 alkyl substituted with C3-C6 cycloalkyl, aryl, heterocyclyl or heteroaryl;
• Each R17 is independently C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or C1-C4 alkyl substituted with C3-C6 cycloalkyl, aryl, heterocyclyl or heteroaryl;
• and
• X is N or CR5.