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US 2010/0063018 A1Published application
Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated diseases or conditions
AssigneeIntercept Pharmaceuticals, Inc.
InventorsRoberto Pellicciari, Stefano Fiorucci, Mark Pruzanski
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Abstract
The present invention relates to compounds of formula (I) wherein: R1 is hydrogen or an alkyl group; R2 is hydrogen or a halogen, nitro, alkyloxy, amino or carboxy group; Y is CH2, oxygen or sulfur; n is an integer from 1 to 4, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof for the treatment of FXR-mediated diseases or conditions.
Claims13
A compound of formula (I)
- wherein:
- R1 is hydrogen or an alkyl group;
- R2 is hydrogen or a halogen, nitro, alkyloxy, amino or carboxy group;
- Y is CH2, oxygen or sulfur;
- and
- n is an integer from 1 to 4, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof.
3 more elements
A compound of formula (I) wherein R1 and R2 are hydrogen, Y is oxygen, and n is 1.
Dependencies are inferred from the claim text.