Cathepsin cysteine protease inhibitors

A compound of the formula:

• wherein Y is hydrogen, CN, —C(O)R8, —C(O)NR8R9, —CH2OH, —C(O)NR8OR9, or —C(O)OR8;
• X is S(O)m, —CH2—, —OC(O)— or —C(O)O—;
• R1 is hydrogen, C1-6 alkyl or C2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with SO2R10, C3-6 cycloalkyl or halo;
• R2 is hydrogen, C1-6 alkyl or C2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with SO2R10, C3-6 cycloalkyl or halo;
• or R1 and R2 can be taken together with the carbon atom to which they are attached to form a C3-8 cycloalkyl ring, C5-8 cycloalkenyl ring, or five to seven membered heterocyclyl wherein said cycloalkyl, cycloalkenyl and heterocyclyl groups are optionally substituted on either the carbon or heteroatom with C1-6 alkyl, halo, hydroxyalkyl, hydroxy, alkoxy or keto;
• R3 is C1-6 alkyl substituted with 1-6 halo;
• R4 is hydrogen, C1-6 alkyl or C2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with C3-6 cycloalkyl or halo;
• R5 is hydrogen, C1-6 alkyl or C2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with C3-6 cycloalkyl or halo;
• or R4 and R5 can be taken together with the carbon atom to which they are attached to form a C3-8 cycloalkyl ring, C5-8 cycloalkenyl ring, or five to seven membered heterocyclyl wherein said cycloalkyl, cycloalkenyl and heterocyclyl groups are optionally substituted on either the carbon or heteroatom with C1-6 alkyl, halo, hydroxyalkyl, hydroxy, alkoxy or keto;
• R6 is hydrogen, C1-6 alkyl or C2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with C3-6 cycloalkyl or halo;
• R7 is hydrogen, C1-6 alkyl or C2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with C3-6 cycloalkyl or halo;
• or R6 and R7 can be taken together with the carbon atom to which they are attached to form a C3-8 cycloalkyl ring, C5-8 cycloalkenyl ring, or five to seven membered heterocyclyl wherein said cycloalkyl, cycloalkenyl and heterocyclyl groups are optionally substituted on either the carbon or heteroatom with C1-6 alkyl, halo, hydroxyalkyl, hydroxy, alkoxy or keto;
• R8 is hydrogen, C1-6 alkyl or C2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with C3-6 cycloalkyl or halo;
• R9 is hydrogen, C1-6 alkyl or C2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with C3-6 cycloalkyl or halo;
• or R8 and R9 can be taken together with the atoms to which they are attached or are between them to form a C3-8 cycloalkyl ring, C5-8 cycloalkenyl ring, or five to seven membered heterocyclyl wherein said cycloalkyl, cycloalkenyl and heterocyclyl groups are optionally substituted on either the carbon or heteroatom with C1-6 alkyl, halo, hydroxyalkyl, hydroxy, alkoxy or keto;
• R10 is C1-6 alkyl, C1-6 haloalkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-6 alkyl), aryl, aryl(C1-6 alkyl), heteroaryl or heteroaryl(C1-6 alkyl), wherein said cycloalkyl group is optionally substituted with C1-6 haloalkyl, and wherein said aryl and heteroaryl groups are optionally substituted with 1 to 3 substituents independently selected from C1-6 alkyl, halo, C1-6 haloalkyl, —SRa, —S(O)Ra, —S(O)2Ra, —ORa, NRcRd, cyano or aryl;
• Ra is hydrogen, C1-6 alkyl, aryl, heteroaryl, aryl(C1-6 alkyl), or heteroaryl(C1-6 alkyl);
• Rb is hydrogen or C1-6 alkyl;
• Rc is hydrogen or C1-6 alkyl;
• Rd is hydrogen or C1-6 alkyl;
• or Rc and Rd can be taken together with the nitrogen atom to which they are attached to form a four to six membered heterocyclyl which may contain a second heteroatom selected from O, S, NH or NC1-6 alkyl;
• D is independently hydrogen, C2-6 alkynyl, aryl, heteroaryl, C3-8 cycloalkyl or heterocyclyl wherein said alkynyl, aryl, heteroaryl, cycloalkyl and heterocyclyl groups, which may be monocyclic or bicyclic, are optionally substituted on either the carbon or the heteroatom with one to five R11;
• R11 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkyloxy, halo, nitro, cyano, aryl, heteroaryl, C3-8 cycloalkyl, heterocyclyl, —C(O)OR13, —OR15, —OR13, —C(O)R13, —R13C(O)R15, —C(O)N(Ra)(Rb), —C(O)N(R13)(R14), —C(R13)(R14)OH, —R15, —C(R13)(R14)N(R15)2, —NR10C(O)NR13S(O)2R15, —SO2R12, —SO(R12), —SO2R15, —SOmN(Rc)(Rd), —SOmCH(R13)(R14), —SO2N(R13)C(O)(R12), —N(R13)(R14), —N(R13)C(O)N(R13)(R15), —N(R13)C(O)R15, —N(R13)C(O)R13, —N(R13)C(O)OR13, —N(R13)SO2(R13), —C(O)C(Ra)(Rb)N(Re)(Rd), —C(Ra)(Rb)N(Rc)C(O)R15, —C(O)C(Ra)(Rb)S(Ra), C(Ra)(Rb)C(O)N(Rc)(Rd);
• wherein said groups are optionally substituted on either the carbon or the heteroatom with one to five substituents independently selected from C1-6 alkyl, halo, keto, cyano, C1-6 haloalkyl, hydroxyalkyl, —OR15, —NO2, —NH2, —NHS(O)2R13, —R15SO2R12, —SO2R12, —SO(R12), —SR12, —SR15, —SOmN(Rc)(Rd), —SOmN(R13)C(O)(R12), —C(R13)(R14)N(R13)(R14), —C(R13)(R14)OH, —COOH, —C(Ra)(Rb)C(O)N(Rc)(Rd), —C(O)(Ra)(Rb), —N(R13)C(R13)(R14)(R15), —N(R13)CO(R15), —NH(CH2)2OH, —NHC(O)OR13, heterocycyl, aryl, or heteroaryl;
• R12 is hydrogen or C1-6 alkyl which is optionally substituted with one, two, or three substituents independently selected from halo, alkoxy, cyano, —NR13 or —SR13;
• R13 is hydrogen or C1-6 alkyl;
• R14 is hydrogen or C1-6 alkyl;
• R15 is hydrogen, aryl, aryl(C1-4) alkyl, heteroaryl, heteroaryl(C1-4)alkyl, C3-8cycloalkyl, C3-8 cycloalkyl(C1-4)alkyl or heterocyclyl(C1-4)alkyl wherein said groups can be optionally substituted with one, two, or three substituents independently selected from halo, alkoxy or —SO2R12;
• m is 0, 1, or 2;
• or a pharmaceutically acceptable salt, stereoisomer or N-oxide derivative thereof.