Compositions and methods for the treatment of inflammatory diseases
AssigneeThe Board of Regents of the University of Oklahoma
InventorRichard F. Harty
Life of this patent
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Abstract
Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5-aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases.
Claims19
A method of treating an inflammatory bowel disease in a mammal by reducing cytokine gene expression in colonic tissue of the mammal, the method comprising
- administering to the mammal by rectal delivery to a colon of the mammal a therapeutically-effective amount of 5-aminosalicylic acid or a pharmaceutically-acceptable salt thereof, and a therapeutically-effective amount of N-acetylcysteine or a pharmaceutically-acceptable salt thereof, whereby administration of the combination of 5-aminosalicylic acid, or a pharmaceutically-acceptable salt thereof, and N-acetylcysteine, or a pharmaceutically-acceptable salt thereof, causes reduced cytokine gene expression in colonic tissue of the mammal.
A method of treating an inflammatory bowel disease in a mammal by reducing myeloperoxidase activity in colonic tissue of a the mammal, the method comprising
- administering to the mammal by rectal delivery to a colon of the mammal a therapeutically-effective amount of 5-aminosalicylic acid or a pharmaceutically-acceptable salt thereof, and a therapeutically-effective amount of N-acetylcysteine or a pharmaceutically-acceptable salt thereof, whereby administration of the combination of 5-aminosalicylic acid, or a pharmaceutically-acceptable salt thereof, and N-acetylcysteine, or a pharmaceutically-acceptable salt thereof, causes reduced myeloperoxidase activity in colonic tissue of the mammal.
A method of treating an inflammatory bowel disease in a mammal, comprising:
- contacting a colonic cell of the mammal with a therapeutically-effective amount of 5-aminosalicylic acid or a pharmaceutically-acceptable salt thereof, and a therapeutically-effective amount of N-acetylcysteine or a pharmaceutically-acceptable salt thereof.
A method of treating an inflammatory bowel disease in a mammal by reducing cytokine gene expression in colonic tissue of a the mammal, the method comprising
- contacting a colonic cell of the mammal with a therapeutically-effective amount of 5-aminosalicylic acid or a pharmaceutically-acceptable salt thereof, and a therapeutically-effective amount of N-acetylcysteine or a pharmaceutically-acceptable salt thereof, whereby the combination of 5-aminosalicylic acid, or a pharmaceutically-acceptable salt thereof, and N-acetylcysteine, or a pharmaceutically-acceptable salt thereof, causes reduced cytokine gene expression in the cell.
A method of treating an inflammatory bowel disease in a mammal by reducing myeloperoxidase activity in colonic tissue of a the mammal, the method comprising
- contacting a colonic cell of the mammal with a therapeutically-effective amount of 5-aminosalicylic acid or a pharmaceutically-acceptable salt thereof, and a therapeutically-effective amount of N-acetylcysteine or a pharmaceutically-acceptable salt thereof, whereby the combination of 5-aminosalicylic acid, or a pharmaceutically-acceptable salt thereof, and N-acetylcysteine, or a pharmaceutically-acceptable salt thereof, causes reduced myeloperoxidase activity in the cell.
Dependencies are inferred from the claim text.