Adenosine Receptor Antagonists

A compound of Formula I having the structure:

• wherein:
• X is selected from the group consisting of —O—, —S—, >NH and >NR′, wherein R′ is selected from the group consisting of hydrogen, C1-C6 acyl and C1-C6 alkyl;
• R1 is selected from the group consisting of RaRbNC(═O)— and HORc—, wherein Ra and Rb are independently selected from the group consisting of hydrogen, optionally substituted C1-C10 alkyl, optionally substituted C1-C10 acyl, formyl, optionally substituted aryl, and optionally substituted arylcarbonyl;
• or Ra and Rb together with the nitrogen atom to which they are attached form an optionally substituted 4- to 8-membered heterocyclic ring;
• and Rc is selected from the group consisting of C1-C6 alkylene, C1-C6 haloalkylene, and carbonyl;
• R2 is selected from the group consisting of hydrogen, hydroxy, amino, azido, halo, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, carboxy, nitrilo, nitro, aryl, thiol, and —Y—CO—Rd, wherein Y is selected from the group consisting of —O—, >NH and —S—, and Rd is selected from the group consisting of —NH2, —OH and C1-C6 alkyl;
• R3 and R4 are independently selected from the group consisting of hydrogen, optionally substituted C1-C10 alkyl, optionally substituted C1-C10 alkoxycarbonyl, optionally substituted C1-C10 acyl, formyl, mono- and di(C1-C10 alkyl)aminocarbonyl, C1-C10 alkylsulphonyl, C1-C10 alkylsulphinyl, optionally substituted aryl, optionally substituted arylcarbonyl, optionally substituted heterocyclyl, optionally substituted heterocyclylcarbonyl, optionally substituted heteroaryl, heteroarylcarbonyl;
• or R3 and R4 together with the nitrogen atom to which they are attached form an optionally substituted 4- to 8-membered heterocyclic ring;
• R5 is selected from the group consisting of hydrogen, halogen, optionally substituted C1-C10 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, hydroxyl, optionally substituted C1-C10 alkoxy, amino, optionally substituted C1-C10 alkylamino, mercapto, and optionally substituted C1-C10 alkylthio;
• and wherein the stereocenters 1, 3, 4 and 7 may be present in any orientation.