Agents and methods for treating pain
AssigneesArbor Vita Corporation, NoNO Inc.
InventorsMichael P. Belmares, Jonathan David Garman, Peter S. Lu, Michael W. Salter, Michael Tymianski
Life of this patent
Estimating the term…
Abstract
The invention provides agents useful for treating pain. An exemplary agent comprises or consists of the a portion of a retroviral Tat protein. One such agent is the peptide Tat-NR2B9c. This peptide has previously been described as an agent for inhibiting damaging effects of stroke and similar conditions via inhibition of PSD95 interactions with NMDA receptors and/or NOS. The present application provides data showing that the Tat-NR2B9c peptides is effective in alleviation of pain. The alleviation of pain can be obtained at a dose of the peptide below the dose required to inhibit PSD-95 interactions with NMDAR or NOS.
Claims23
A method of treating pain, comprising administering a peptide having an amino acid sequence comprising YGRKKRRQRRRKLSSIESDV (SEQ ID NO:1) or a variant having fewer than ten deletions, substitutions or insertions of the sequence, or a peptidomimetic of the sequence or variant to a patient experiencing or at risk of pain in a regime effective to treat or effect prophylaxis of the pain.
(canceled)
A method of treating pain, comprising administering a tat peptide having an amino acid sequence comprising YGRKKRRQRRR (SEQ ID NO:2) or a variant thereof having fewer than 4 deletions, substitutions or insertions of the sequence or a peptidomimetic of the tat peptide or variant to a patient experiencing or at risk of pain in a regime effective to treat or effect prophylaxis of the pain.
(canceled)
(canceled)
Dependencies are inferred from the claim text.