Fgf-23 polypeptides
OwnerRajiv Kumar, Theresa J. Berndt +1inventors
InventorsRajiv Kumar, Theresa J. Berndt, Theodore A. Craig
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Abstract
This document relates to FGF-23 polypeptides, FGF-23 polypeptide fragments, and methods for making and using such polypeptides and polypeptide fragments. For example, FGF-23 polypeptide fragments that can be used to treat disorders associated with hyperphosphatemia such as chronic renal failure and hypoparathyroidism are provided.
Claims12
A substantially pure polypeptide comprising the sequence set forth in SEQ ID NO:9 and lacking the sequence set forth in SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, or SEQ ID NO:14.
A composition comprising a polypeptide comprising the sequence set forth in SEQ ID NO:9 and lacking the sequence set forth in SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, or SEQ ID NO:14.
A method for treating a disorder associated with hyperphosphatemia, said method comprising administering a polypeptide to a mammal under conditions wherein the severity of a symptom of said disorder is reduced, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:9 and lacks the sequence set forth in SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, or SEQ ID NO:14.
A method for reducing the serum phosphate level in a mammal, said method comprising administering a polypeptide to a mammal under conditions wherein said serum phosphate level in said mammal is reduced, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:9 and lacks the sequence set forth in SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, or SEQ ID NO:14.
A method for increasing phosphate excretion in a mammal, said method comprising administering a polypeptide to a mammal under conditions wherein phosphate excretion is increased in said mammal, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:9 and lacks the sequence set forth in SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, or SEQ ID NO:14.
Dependencies are inferred from the claim text.