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US 2010/0062971 A1Published application
Substituted indazole-o-glucosides
AssigneeJanssen Pharmaceutica NV
InventorsMona Patel, Philip J. Rybczynski, Maud Urbanski, Xiaoyan Zhang
Life of this patent
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Abstract
Substituted indazole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
Claims19
A compound of formula (II):
- wherein
- R1 is H or C1-4 alkyl;
- R2 is H, F, Cl, methoxy, or C1-3 alkyl;
- Q is (CH2)n— where n=0, 1, or 2;
- or, where R2 is H, F, Cl, or methoxy, then Q can also be selected from —CH2—S—;
- Z is substituted or unsubstituted, and is selected from C3-7 cycloalkyl, phenyl, benzhydryl, 5- or 6-membered heteroaryl having 1 or 2 heteroatoms independently selected from N, O, and S, a biaryl, and a 9- or 10-membered fused bicyclyl or fused heterobicyclyl, wherein each fused heterobicyclyl has between 1 and 4 heteroatoms independently selected from N, O, and S;
- P═H or acetyl;
- or a pharmaceutically acceptable salt thereof.
5 more elements
9-18. (canceled)
(canceled)
23-28. (canceled)
A method for treating diabetes or Syndrome X, or associated symptoms or complications thereof in a subject, comprising
- (a) administering to said subject a jointly effective amount of a compound of formula (II);
- and
- (b) administering to said subject a jointly effective amount of a second antidiabetic agent,
- said co-administration being in any order and the combined jointly effective amounts providing the desired therapeutic effect.
1 more element
30-33. (canceled)
36-51. (canceled)
Dependencies are inferred from the claim text.