Novel strategies for delivery of active agents using micelles and particles
OwnerBali Pulendran, Niren Murthy +4inventors
InventorsBali Pulendran, Niren Murthy, Robert H. Pierce, Michael John Heffernan, Jihua Hao, Marcin Kwissa
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Abstract
The present invention provides biodegradable particles (e.g., three-dimensional particles) and micelles which can be used to encapsulate active agents for delivering to a subject. The present invention further provides methods for producing and delivering such particles and micelles. Additionally, the invention provides vaccination strategies that encompass the use of the novel particles and micelles.
Claims61
A biodegradable hydrophobic polyketal polymer comprising ketal groups, wherein each ketal group of the polymer has two oxygen atoms within the polymer backbone.
A biodegradable crosslinked micelle comprising multiple polymers, wherein said polymers are crosslinked by an external crosslinking agent, wherein said external crosslinking agent comprises (a) at least two thiol groups or (b) an antigen.
A reversibly modified active agent which can easily be encapsulated in a micelle.
A method for reversibly modify proteins to be easily encapsulated in a micelle comprising reacting the amino groups of said proteins with an agent that increases the number of charged sites in said protein and thereby modifying the charge of the protein.
Dependencies are inferred from the claim text.