Benzophenone or Benzoic Acid Anilide Derivatives containing Carboxyl Groups as Enzyme Stabilizers
AssigneeHenkel AG & Co. KGaA
InventorsAndreas Michels, Robin Ghosh, Cornelius Bessler, Daniela Lowis
Life of this patent
Estimating the term…
Abstract
Washing and cleaning agents containing benzophenone or benzole anilide derivatives containing carboxyl groups, which function as protease inhibitors and are suitable as enzyme stabilizers. Additional subjects are the use of such compounds as reversible inhibitors of a protease and consequently for a washing or cleaning agent formulation, and additional methods and uses relating thereto.
Claims15
A washing or cleaning agent, comprising a protease and a stabilizing compound of the general structural formula
- in which
- (a) X stands for a carbonyl group (C═O) or an acid amide group (NHCO),
- (b) R1, R2, R3, R4 and R5 (in ring 1) stand for hydrogen (H), a carboxyl group (COOH), a methyl group (CH3), an ethyl group (C2H5), a hydroxyl group (OH), a hydroxymethyl group (CH2OH), an amino group (NH2) and/or a halogen, such that at least one carboxyl group (COOH) is present in ring 1;
- (c) R6, R7, R8, R9 and R10 (in ring 2) stand for hydrogen (H), a carboxyl group (COOH), a methyl group (CH3), an ethyl group (C2H5), a hydroxyl group (OH), a hydroxymethyl group (CH2OH), an amino group (NH2) and/or a halogen, such that at least one carboxyl group (COOH) is present in ring 2;
- and
- (d) optionally two of the radicals R1 to R10 (A) and (B) are in ortho position to one another, (A) being an obligatory carboxyl group (COOH) mentioned in (b) and/or (c) or optionally an additional carboxyl group, and (B) being a hydroxymethyl group, which are present as such groups or optionally as the group CH2—O—CO— and thus together with the carbon atoms of the ring containing them denote a five-membered lactone.
A method of reversibly inhibiting a protease in a washing or cleaning agent, comprising the steps of forming a washing or cleaning agent comprising a protease and an amount of a stabilizing compound of the general structural formula
- in which
- (a) X stands for a carbonyl group (C═O) or an acid amide group (NHCO),
- (b) R1, R2, R3, R4 and R5 (in ring 1) stand for hydrogen (H), a carboxyl group (COOH), a methyl group (CH3), an ethyl group (C2H5), a hydroxyl group (OH), a hydroxymethyl group (CH2OH), an amino group (NH2) and/or a halogen, such that at least one carboxyl group (COOH) is present in this ring,
- (c) R6, R7, R8, R9 and R10 (in ring 2) stand for hydrogen (H), a carboxyl group (COOH), a methyl group (CH3), an ethyl group (C2H5), a hydroxyl group (OH), a hydroxymethyl group (CH2OH), an amino group (NH2) and/or a halogen, such that at least one carboxyl group (COOH) is present in this ring, and
- (d) optionally two of the radicals R1 to R10 are (A) and (B), which are
- in ortho position to one another, (A) being an obligatory carboxyl group (COOH) mentioned in (b) and/or (c) or optionally an additional carboxyl group, and (B) being a hydroxymethyl group, which are present as such groups or optionally as the group CH2—O—CO— and thus together with the carbon atoms of the ring containing them denote a five-membered lactone,
- effective to inhibit the activity of the protease during storing conditions.
A method of making a washing or cleaning agent, comprising the steps of combining a protease and a compound of the general structural formula
- in which
- (a) X stands for a carbonyl group (C═O) or an acid amide group (NHCO),
- (b) R1, R2, R3, R4 and R5 (in ring 1) stand for hydrogen (H), a carboxyl group (COOH), a methyl group (CH3), an ethyl group (C2H5), a hydroxyl group (OH), a hydroxymethyl group (CH2OH), an amino group (NH2) and/or a halogen, such that at least one carboxyl group (COOH) is present in this ring,
- (c) R6, R7, R8, R9 and R10 (in ring 2) stand for hydrogen (H), a carboxyl group (COOH), a methyl group (CH3), an ethyl group (C2H5), a hydroxyl group (OH), a hydroxymethyl group (CH2OH), an amino group (NH2) and/or a halogen, such that at least one carboxyl group (COOH) is present in this ring, and
- (d) optionally two of the radicals R1 to R10 are (A) and (B), which are in ortho position to one another, (A) being an obligatory carboxyl group (COOH) mentioned in (b) and/or (c) or optionally an additional carboxyl group, and (B) being a hydroxymethyl group, which are present as such groups or optionally as the group CH2—O—CO and thus together with the carbon atoms of the ring containing them denote a five-membered lactone.
Dependencies are inferred from the claim text.