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US 2010/0062949 A1Published application
Fiber optic device
AssigneeMabgen, LLC
InventorDENNIS LEE
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AssigneeMabgen, LLC
InventorDENNIS LEE
Estimating the term…
The present invention is directed to a fiber optic device consisting of a fiber bundle having multiple legs of silica fibers, using a plurality of microspheres construct to attach target cells, for the assay of cytotoxic compounds. Each leg of silica fibers consists of twenty-five or more silica fibers treated with biotin and streptavidin treated microspheres which chemically bind the microspheres to the silica fibers. Further, the present invention is directed to the unique microspheres. The microspheres have a core, preferably alginate, with an outer surface of chitosan. The present invention is further directed to the use of the described fiber optic device to isolate, research and develop biological medicaments and diagnostic cytotoxic compounds. The fiber optic device utilizes thousands of fibers and the unique microspheres to provide a high-throughput screening device.
A fiber optic device to assay libraries of cytotoxic compounds comprising:
Microspheres ranging from 5 to 500 or greater microns consisting of a core and an outer surface of chitosan.
A leg of twenty-five (25) or more silica fibers having microspheres at the distal end, said microspheres comprising a core and an outer surface of chitosan.
A leg of twenty-five (25) or more silica fibers treated with biotin to attach microspheres at the distal end, said microspheres comprising a core and an outer surface of chitosan treated with streptavidin to chemically bind said microspheres to said silica fibers.
A bundle of twenty-five or more silica fibers treated with biotin and having floatable microspheres treated with streptavidin to bind said microspheres to said silica fibers.
A fiber optic device to assay libraries of cytotoxic compounds comprising:
A method to assay cytotoxic compounds comprising:
A method to assay cytotoxic compounds from cancer patients comprising:
Dependencies are inferred from the claim text.