Adiponectin receptor and gene encoding the same
AssigneesToudai TLO, Ltd., Nissan Chemical Industries, Ltd.
InventorsTakashi Kadowaki, Toshimasa Yamauchi, Ryozo Nagai, Junji Kamon
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Abstract
The object is to isolate and identify human and mouse adiponectin receptors, to provide a novel protein having adiponectin binding ability, and to provide a screening method and screening kit for a ligand, agonist and antagonist to an adiponectin receptor using such protein. To achieve this object, a protein is used, as novel protein having adiponectin binding ability, that is (a) a protein comprising an amino acid sequence according to Seq. No. 2, 4, 6 or 8, or (b) a protein comprising an amino acid sequence according to Seq. No. 2, 4, 6 or 8 with one or more amino acids deleted, replaced or added, and having adiponectin binding ability.
Claims8
An isolated protein comprising the amino acid sequence according to SEQ ID NO:
- 2 or 4.
An isolated protein comprising the amino acid sequence with one to ten amino acid deletions, substitutions or additions to the amino acid sequence of SEQ ID NO:2 or 4.
An isolated protein comprising the amino acid sequence with one to ten amino acid deletions, substitutions or additions to the amino acid sequence of SEQ ID NO:2 or 4, wherein the protein has adiponectin binding activity.
An isolated protein comprising the amino acid sequence which is at least 90% identical to the entire amino acid sequence of SEQ ID NO:2 or 4.
An isolated protein comprising the amino acid sequence which is at least 90% identical to the entire amino acid sequence of SEQ ID NO:2 or 4, wherein the protein has adiponectin binding activity.
An isolated protein consisting of the amino acid sequence according to SEQ ID NO:2 or 4.
An isolated protein consisting of the amino acid sequence which is at least 90% identical to the entire amino acid sequence of SEQ ID NO:2 or 4, wherein the protein has adiponectin binding activity.
Dependencies are inferred from the claim text.