Silica particles modified with polar organic moieties
OwnerRowell Frederick, Sundar Lathainventors
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Abstract
The present disclosure relates to silica particles and, in embodiments, to organically-substituted silica particles. The particles are useful for the adsorption of compounds, particularly the adsorption and desorption of compounds in for example matrix assisted mass spectroscopy techniques or chromatographic techniques. The present disclosure further relates to such techniques, the preparation of the particles and other subject matter.
Claims22
-32. (canceled)
The use of a silica particle comprising a polar organic moiety as a matrix material for matrix assisted laser desorption/ionisation-time-of-flight mass spectrometry (MALDI-TOF-MS).
A method of performing MALDI-TOF-MS, comprising:
- placing into a MALDI-TOF-MS analyser particles comprising an organic moiety capable of both hydrophobic-hydrophobic interactions and an additional interaction selected from the group consisting of dipole-dipole interactions, hydrogen bonding interactions, and charge transfer interactions, and combinations thereof;
- illuminating the particles with a laser;
- and
- measuring the time of flight of the ionised molecules that are formed as a result of the laser illumination.
The method of clam 36, wherein the particles comprise a polar organic moiety which comprises a hydrocarbyl moiety substituted by one or more functional groups.
The method of 36, wherein the particles are obtainable by a process involving reaction of a silane ether monomer and an organically-substituted silane ether monomer.
A MALDI-TOF-MS material comprising a silica particle having a polar organic moiety.
The use of a silica particle comprising a polar organic moiety to adsorb a polar organic compound.
In a MALDI-TOF-MS method, the improvement comprising the use of particles which comprise a polar organic moiety.
Dependencies are inferred from the claim text.