Rearranged squamous cell carcinoma antigen genes ii
AssigneeCanAg Diagnostics AB
InventorEva Röjer
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Abstract
The present invention relates to a SCCA1/SCCA2 fusion protein; plasmid containing the same; antibodies of said fusion protein; methods for detecting said protein; methods for diagnosing the presence or absence of SCC by determining the presence of SCCA1/SCCA2 fusion protein.
Claims14
A fusion transcript consisting of a homologue cross-over between two different genes having more than 80% sequence homology wherein the cross-overs are coded by exons 2-7 of the Squamous Cell Carcinoma Antigen 1 (SCCA1) gene fused to exon 8 of the Squamous Cell Carcinoma Antigen 2 (SCCA2) gene having the order exons 2-7 of SCCA1 followed by exon 8 of SCCA2, and the exons 2-7 of the SCCA2 gene fused to exon 8 of the SCCA1 gene having the order exons 2-7 of SCCA2 followed by exon 8 of SCCA1, wherein the fusion transcript is expressed in vivo in Squamous Cell Carcinoma.
3-11. (canceled)
A plasmid comprising the nucleotide sequence corresponding to exons 2-7 of the SCCA1 gene fused to the nucleotide sequence of exon 8 of SCCA2 gene.
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18-19. (canceled)
22-44. (canceled)
Dependencies are inferred from the claim text.