Nerolidol, Terpene, and Terpene Deriviative Synthesis
AssigneeWilliam Marsh Rice University
InventorsCaroline Virginia McNeil, Pietro Morlacchi, Alyssa Baevich, Seiichi Paul Tillich Matsuda
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Abstract
According to one embodiment, the description relates to a method of nerolidol production. The method includes culturing a yeast strain lacking functional squalene synthase and overproducing HMG CoA reductase in synthetic medium lacking uracil and producing nerolidol. The pH of the medium may be adjusted to an acidic level to further increase nerolidol production. Other chemicals may also be produced by this method. The nerolidol or other chemicals may be removed from the yeast or medium or both. The medium may additionally contain a polyaromatic resin, which may adsorb nerolidol or other chemicals.
Claims20
A method of nerolidol production comprising:
- culturing a yeast strain lacking functional squalene synthase and overproducing HMG CoA reductase in synthetic medium lacking uracil;
- and
- producing nerolidol.
The method according to claim 12, further comprising producing farnesol.
Dependencies are inferred from the claim text.