Pharmaceutical compositions comprising nanoparticles comprising enteric polymers casein

A pharmaceutical composition comprising an

• aqueous suspension, said aqueous suspension comprising:
• (a) nanoparticles comprising a poorly water soluble drug and an enteric polymer, wherein
• (i) said poorly water soluble drug has a water solubility of less than 5 mg/mL at a pH of 6.5 to 7.5,
• (ii) at least 90 wt % of said drug in said nanoparticles is in a noncrystalline form,
• (iii) said nanoparticles have an average diameter of less than 500 nm,
• (iv) said poorly water soluble drug and said enteric polymer together constitute at least 60 wt % of said nanoparticles, and
• (v) the mass ratio of said poorly water soluble drug to said enteric polymer is less than 9:1;
• (b) casein or a pharmaceutically acceptable form thereof;
• and
• (c) water.