Particle Formulations and Uses Thereof
AssigneeParticle Sciences, Inc.
InventorsAndrew Loxley, Mark Mitchnick, David Fairhurst, Christy Ann Eatmon
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Abstract
Aqueous dispersions of chemically and physically stable particles for use in delivery of active pharmaceutical ingredients and processes for their production and use to enhance a biological response to an active pharmaceutical ingredient and prophylactically or therapeutically treat a subject are provided. Vaccines, wherein the active pharmaceutical ingredient is a solution of subunit vaccine antigen mixed with a colloidal dispersion of electrically charged particles and use of such vaccines in immunization are also provided.
Claims19
An aqueous dispersion of chemically and physically stable particles having an average diameter of less than 100 μm, said particles comprising a hydrophobic organic material stable to aqueous hydrolysis which interacts with a co-dissolved or co-dispersed active pharmaceutical ingredient.
(canceled)
A vaccine comprising a colloidal dispersion of electrically charged particles having an average diameter of less than 100 μm mixed with a solution of subunit vaccine antigens.
Dependencies are inferred from the claim text.