Pharmaceutical composition containing naphthoquinone-based compound for intestine delivery system
AssigneesMazence Inc., Kt & G Cp., Ltd
InventorsIn Geun Jo, Sang-Ku Yoo, Myung-gyu Park, Taehwan Kwak
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Abstract
Provided is an oral pharmaceutical composition with improved bioavailability and pharmacokinetic properties of a drug, by increasing a bioabsorption rate and an in vivo retention time of an active ingredient via intestine-targeted formulation of a particular naphthoquinone-based compound, or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, as an active ingredient.
Claims39
An oral pharmaceutical composition wherein a naphthoquinone-based compound represented by Formula 1 below, or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, as an active ingredient, is prepared into an intestine-targeted formulation:
- wherein
- alkoxy,
- R1 and R2 are each independently hydrogen, halogen, hydroxy, or C1-C6 lower alkyl or
- R3, R4, R5, R6, R7 and R8 are each independently hydrogen, hydroxy, C1-C20 alkyl, alkene or alkoxy, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, or two substituents of R3 to R8 may be taken together to form a cyclic structure which may be saturated or partially or completely unsaturated;
- X is selected from the group consisting of C(R)(R′), N(R″), O and S, wherein R, R′ and R″ are each independently hydrogen or C1-C6 lower alkyl;
- and
- n is 0 or 1, with proviso that when n is 0, carbon atoms adjacent to n form a cyclic structure via a direct bond.
Dependencies are inferred from the claim text.