Formulation
AssigneePronova Biopharma Norge AS
InventorsGunnar BERGE, Svein Olaf Hustvedt, Thomas Andersen
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Abstract
Novel capsules comprising a marine oil in an outer shell comprising alginate are disclosed. Also disclosed are methods of preparing the novel capsules and uses of thereof.
Claims27
A seamless capsule comprising a polysaccharide gel membrane outer surface shell comprising at least one alginate wherein:
- said outer surface encapsulates at least one emulsion comprising at least one oily phase,
- said at least one oily phase comprises at least one marine oil and at least one surfactant,
- said marine oil comprises at least 50% by weight of said emulsion, and
- said emulsion does not comprise marmelo mucilage.
A seamless capsule comprising a polysaccharide gel membrane outer surface shell comprising at least one alginate, wherein said outer surface encapsulates at least one emulsion comprising at least one oil-in-water emulsion comprising:
- about 85% of at least one marine oil by weight of said emulsion;
- wherein said marine oil comprises about 90% omega-3 ethyl ester fatty acids by weight of said marine oil;
- and
- wherein about 84% by weight of said omega-3 ethyl ester fatty acids comprise eicosapentaenoic acid ethyl ester and docosahexaenoic acid ethyl ester by weight of said omega-3 ethyl ester fatty acids;
- about 0.1% to about 3% surfactant by weight of said emulsion;
- about 0.1% to about 6% CaCl2.2H2O by weight of said emulsion;
- and
- about 1% to about 15% water by weight of said emulsion.
A method of regulating at least one health problem chosen from irregular plasma lipid levels, cardiovascular functions, immune functions, visual functions, insulin action, neuronal development, hypertriglyceridemia, heart failure, and post myocardial infarction, comprising administering to a subject in thereof a seamless capsule comprising:
- a polysaccharide gel membrane outer surface shell comprising at least one alginate, wherein:
- said outer surface encapsulates at least one emulsion comprising at least one oily phase,
- said at least one oily phase comprises at least one marine oil or marine oil composition and at least one surfactant,
- said marine oil comprises at least 50% by weight of said emulsion, and
- said emulsion does not comprise marmelo mucilage.
Dependencies are inferred from the claim text.