Encapsulated picoplatin
AssigneePoniard Pharmaceuticals, Inc.
InventorsAlistair J. Leigh, Christopher A. Procyshyn, Angelica Phillips, Hazel B. Breitz
Life of this patent
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Abstract
The invention provides an encapsulated unit dosage form for picoplatin that is adapted for oral administration of the picoplatin containing a substantially dry powder with about 20 to 55 wt % picoplatin in the physical form of a picoplatin particulate wherein an average picoplatin particle diameter is less than about 10 microns. The picoplatin particles are dispersed within the powder of the formulation which includes a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate and an effective amount of up to about 5 wt % of a lubricant.
Claims67
A unit dosage form for picoplatin, adapted for oral administration of the picoplatin, comprising a substantially water-soluble capsule shell, the capsule shell enclosing a formulation comprising a substantially dry powder comprising about 10 to 60 wt % particulate picoplatin, a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt % of a lubricant.
A process for preparing an encapsulated unit dosage form for picoplatin, adapted for oral administration of the picoplatin, comprising preparing a formulation comprising a substantially dry powder comprising about 10 to 60 wt % particulate picoplatin, a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt % of a lubricant;
- and enclosing the formulation within a substantially water-soluble capsule shell.
A method of treating cancer comprising (a) consecutive oral daily administration of at least one unit dosage form comprising picoplatin to a human afflicted with cancer, so as to attain the optimal therapeutic level of picoplatin in the circulation of the human;
- and (b) discontinuing said administration for a period of time effective for the mammal to substantially eliminate said picoplatin from its circulation.
The method of treating cancer comprising (a) consecutive daily oral administration of said at least one unit dosage form comprising picoplatin to a human afflicted with cancer, so as to achieve a uniform sub-maximal level of said picoplatin in the circulation of the human;
- and (b) discontinuing said administration for a period of time effective for the human to substantially eliminate said picoplatin from its circulation.
Dependencies are inferred from the claim text.