Back to results
US 2010/0062054 A1Published application
Lipobeads and their production
AssigneePolytechnic Institute of New York University
InventorsSergey Kazakov, Marian Kaholek, Kalle Levon
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneePolytechnic Institute of New York University
InventorsSergey Kazakov, Marian Kaholek, Kalle Levon
Estimating the term…
Lipobeads (liposome-encapsulated hydrogels) combine properties of hydrogels and liposomes to create systems that are sensitive to environmental conditions and respond to changes in those conditions in a fast time scale. Lipobeads may be produced by polymerizing anchored or unanchored hydrogels within liposomes or by mixing anchored or unanchored hydrogels with liposomes. Giant lipobeads may be produced by shrinking unanchored nanogels in lipobeads and fusing the resulting lipobead aggregates, long-term aging of anchored or unanchored lipobeads, or mixing anchored or unanchored aggregated nanogels with liposomes. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide-co-1-vinylimidazole) lipobeads were produced and characterized.
A method for producing an anchored lipobead defined by a hydrogel, having a diameter of less than 1 μm, encapsulated in a lipid bilayer, the method comprising:
A method for producing a giant lipobead defined by an aggregated plurality of hydrogel particles, each having a diameter less than 1 μm, encapsulated in a lipid bilayer, the method comprising incubating a solution of anchored or unanchored lipobeads for more at least one month, thereby aggregating lipobeads and forming giant lipobeads.
The method of claim 21 wherein the combined giant lipobead contains hydrogels loaded with different compartments.
The method of claim 21 wherein the combined giant lipobead contains hydrogels filled with different liquid media.
The method of claim 21 wherein the combined giant lipobead contains hydrogels functionalized with different ligands.
The method of claim 21 wherein the combined giant lipobead generated has a diameter of approximately 100 nm to approximately 3000 nm.
Dependencies are inferred from the claim text.