Method of Treating a Malignancy in a Subject Via Direct Picornaviral-Mediated Oncolysis
AssigneeViralytics Limited
InventorDARREN R. SHAFREN
Life of this patent
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Abstract
There are provided methods for treatment of abnormal cells such as cancer cells in a mammal. The methods involve treating the mammal with virus selected from echoviruses and modified forms and combination thereof, which recognize α2β1 for infectivity of the cells. There are also provided methods for screening viruses for use in a method of the invention as well as pharmaceutical compositions for use in the methods.
Claims33
A method for treatment of abnormal cells in a mammal, the method comprising treating the mammal with an effective amount of virus selected from echo-viruses, and modified forms and combinations thereof, which recognise α2β1 for infectivity of the cells such that at least some of the cells are killed by the virus.
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A method for inducing an immune response in a mammal against abnormal cells expressing α2β1, the method comprising infecting abnormal cells in the mammal with virus selected from echoviruses, and modified forms and combinations thereof, whereby lysis of at least some of cells is caused.
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A pharmaceutical composition for treating abnormal cells in a mammal, comprising an inoculant for generating virus to treat the cells such that at least some of the cells are killed by the virus together with a pharmaceutically acceptable carrier, wherein the virus is selected from echoviruses, and modified forms and combinations thereof, which recognise α2β1 for infectivity of the cells.
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Dependencies are inferred from the claim text.