Peptide Vaccine for Inducing the Production of Anti-Amyloid ß-Peptide Antibody
AssigneeKabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
InventorAkira Yano
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Abstract
An object of the present invention is to provide a peptide vaccine for preventing and/or treating diseases caused by amyloid β-peptide, such as Alzheimer's disease. The present invention solves the above object by providing a peptide vaccine constructed by inserting a peptide having an amino acid sequence of a cell attachment motif of a cell adhesive molecule to a peptide which consists of a peptide having an amino acid sequence of multiagretope type T-cell epitope, which has been generated immunological memory, or a peptide including the same; an linker peptide; and a peptide having an amino acid sequence of a B cell epitope which is a specific region of amyloid β-peptide or a peptide including the same.
Claims5
A peptide, having an amino acid sequence represented by the following general formula.
- R1-T-R2-L-R3—B—R4 General formula:
- wherein the symbol “T” means an amino acid sequence including an amino acid sequence of T-cell epitope which has been generated immunological memory;
- the symbol “L” means an amino acid sequence of a linker peptide;
- the symbol “B” means an amino acid sequence including one or more amino acid sequences of B-cell epitope of amyloid β-peptide;
- and the symbols “R1”, “R2”, “R3” and “R4” mean one or more positions where an amino acid sequence(s) of cell attachment motif peptides of cell adhesive molecules can be located.
Dependencies are inferred from the claim text.