Novel stromal cell-derived factor-1 polypeptides, polynucleotides, modulators thereof and methods of use
AssigneeFive Prime Therapeutics, Inc.
InventorsKeting Chu, Lewis T. Williams, Justin G.P. Wong, Kevin Hestir, Amy L. Tsui Collins, Ernestine Lee
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Abstract
Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.
Claims51
A first isolated nucleic acid molecule comprising a first polynucleotide sequence chosen from (A) SEQ. ID. NOS.:1, 6-8, and 17;
- (B) a polynucleotide sequence encoding a polypeptide of SEQ. ID. NO.:9, 14-16, 22-23;
- (C) biologically active fragments thereof;
- and (D) complements thereof.
2-4. (canceled)
An isolated polypeptide comprising an amino acid sequence, wherein the amino acid sequence is chosen from SEQ. ID. NO.:9, 14-16, and 22-23.
6-18. (canceled)
20-24. (canceled)
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28-30. (canceled)
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62-63. (canceled)
65-66. (canceled)
68-74. (canceled)
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A method for promoting tissue regeneration in a subject comprising:
- (a) providing a polypeptide comprising an amino acid sequence chosen from SEQ. ID. NOS.:9 and 14-16;
- and
- (b) administering the polypeptide to the subject.
122-131. (canceled)
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135-146. (canceled)
A polypeptide comprising the amino acid sequence of amino acids 22-88 of CLN00235738—5pv1.a and further comprising at least one additional amino acid chosen from amino acids 89-140, wherein polypeptide comprises a contiguous sequence of amino acids chosen from CLN00235738—5pv1.a as shown in FIG. 1.
Dependencies are inferred from the claim text.