Immunotherapy To Treat Or Prevent Viral Infection
OwnerDamian Michael Carragher, Denise Ann Kaminski +2inventors
InventorsDamian Michael Carragher, Denise Ann Kaminski, Frances E. Lund, Troy Douglas Randall
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Abstract
The prevention and treatment of influenza is described, by using passive immunization with antibodies (e.g. polyclonal, monoclonal, etc.) to one or more conserved influenza proteins. Both antibodies and fragments thereof are contemplated, raised against conserved proteins such as nucleoproteins.
Claims46
A method for treating a viral infection comprising:
- a) providing:
- i) a subject exhibiting symptoms of a viral infection,
- ii) a composition comprising antibody or fragment thereof reactive with a viral nucleoprotein;
- b) administering said composition to said subject under conditions such that said symptoms are reduced.
A method for treating an Influenza A viral infection comprising:
- a) providing:
- i) a subject exhibiting symptoms of an Influenza A viral infection,
- ii) a composition comprising antibody or a fragment thereof reactive with Influenza A viral protein selected from the group consisting of PB1, PB2, PA, NP, NS1, NS2, M1, M2 and PB1-F2;
- b) administering said composition to said subject under conditions such that said symptoms are reduced.
A method for protecting against an Influenza A viral infection comprising:
- a) providing:
- i) a subject at risk for an Influenza A viral infection,
- ii) a composition comprising antibody or fragment thereof reactive with Influenza A viral protein selected from the group consisting of PB1, PB2, PA, NP, NS1, NS2, M1, M2 and PB1-F2;
- b) administering said composition to said subject prior to any symptoms of infection.
A method for treating a viral infection comprising:
- a) providing:
- i) a subject exhibiting symptoms of a viral infection,
- ii) a composition comprising a vector encoding antibody or an antibody fragment reactive with a viral nucleoprotein;
- b) administering said composition to said subject under conditions such that antibody is produced in said subject and said symptoms are reduced.
Dependencies are inferred from the claim text.