Therapeutic uses of tim-3 modulators
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsDavid E. Anderson, Ana C. Anderson, Vijay K. Kuchroo, David A. Hafler
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Abstract
The invention provides novel methods of treating neurological disorders, including neurodegenerative disorders such as MS. The invention also provides novel methods of treating cancers, including glial tumors such as glioblastoma multiforme. The invention further provides vaccines and related uses.
Claims61
A method of treating multiple sclerosis in a subject in need of such treatment, the method comprising a) assessing whether the subject is in the remitting/relapsing or the secondary, progressive stage of multiple sclerosis, and, b) if said subject is determined to be in the secondary, progressive stage of multiple sclerosis, administering to the subject a therapeutically effective amount of an agent that decreases TIM-3 activity in the subject.
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A method of enhancing an immune response, the method comprising administering a Toll-like Receptor (TLR) agonist and an agent that increases a TIM-3 activity to a subject in need of an enhanced immune response.
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A vaccine composition comprising an agent that increases TIM-3 activity and a TLR ligand.
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A method of vaccinating an animal against an antigen, the method comprising administering to the animal an agent that increases TIM-3 activity, and a TLR ligand.
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Dependencies are inferred from the claim text.